Ganoderic acid H( —— )

Catalog No. M29149 CAS No. 98665-19-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Ganoderic acid H
Note

Research use only, not for human use.
Brief Description

Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-κB, resulting in the suppression of secretion of uPA.
Description

Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-κB, resulting in the suppression of secretion of uPA.(In Vitro):In highly invasive human breast cancer cells, Ganoderic acid H suppressed growth (cell proliferation and colony formation) and invasive behavior (adhesion, migration and invasion) of MDA-MB-231 cells. Furthermore, the activity of Ganoderic acid H is linked to the hydroxylation in the positions 7 and 3 in its triterpene lanostane structure. Ganoderic acid H could be a promising natural agent for the therapy of invasive breast cancers.
In Vitro

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In Vivo

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Synonyms

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Pathway

Apoptosis
Target

NF-κB
Recptor

NF-κB
Research Area

——
Indication

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CAS Number

98665-19-1
Formula Weight

572.695
Molecular Formula

C32H44O9
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (174.61 mM)
SMILES

[H][C@@]12CC(=O)C3=C(C(=O)[C@@H](OC(C)=O)[C@]4(C)[C@H](CC(=O)[C@@]34C)[C@H](C)CC(=O)CC(C)C(O)=O)[C@@]1(C)CC[C@H](O)C2(C)C
Chemical Name

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